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Note
The proceedings for Affinity 2007 will be published in the Journal of Molecular Recognition. Please contact Gidi Fleminger (gidifl@post.tau.ac.il) and/or George Ehrlich (gke1@nyu.edu) if you are interested in publishing your work.
Sunday July 8, 2007
| Affinity 2007 Welcoming Reception |
Welcome and Introduction
George Ehrlich, Hoffmann - La Roche, Nutley, NJ |
Keynote Lecture
A Human Protein Atlas Based on Affinity Proteomics
Mathias Uhlén
Department of Biotechnology, AlbaNova University Center, Royal Institute of
Technology, Stockholm, Sweden |
Monday July 9, 2007
Opening Ceremonies
Richard Willson, University of Houston, Houston, TX |
Session 1: Affinity: Past, Present and Future
Mathias Uhlén, Royal Institute of Technology, Stockholm, Sweden
| Chairman Introduction |
| 101 |
My Life with Affinity: Essentials of Biorecognition and its Application
Meir Wilchek
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel |
| 102 |
Monolith Supports with Affinity and Pseudo Affinity Ligands for Superfast
Purification of Biomolecules
M. A. Vijayalakshmi1,2,
1Laboratoire d'Interactions Moléculaires et de Technologie de Séparation (LIMTech.S),
Centre de Recherche de Royallieu, BP 20.529, 60205 Compiègne Cedex, France
2Center for BioSeparations Technology, VIT University, Vellore, 632014, India |
| 103 |
Immunodepletion - What's Beneath the Tip of the Plasma Proteome
Iceberg?
Mark S. Baker1,2, Alamgir Khan1, Wai-Kei Shum2, Sock-Hwee Tan2, Veronika
Polaskova2 and Amit Kapur2
1Australian Proteome Analysis Facility Ltd (APAF), 2Dept. of Chemistry and Biomolecular Sciences,
Macquarie University, 2109. Sydney, Australia |
| 104 |
The NCI’s Clinical Proteomic Technology Initiative for Cancer - The
Reagent Resource Core
Adam Michael Clark
National Cancer Institute, Office of Technology and Industrial Relations, Bethesda MD |
Lunch Work-
shop |
Flexible Formats for Characterizing and Screening Protein-Protein
Interactions using Bio Layer Interferometry on the Octet System
Matthew Kirtley
ForteBio, Inc. Menlo Park, CA USA |
Session 2: Advances in Affinity Technologies
Lars Hagel, GE Healthcare, Uppsala, Sweden
| Chairman Introduction |
| 201 |
Evolution of Industrial Affinity in Biopharmaceutical Production
Duncan Low
Process Development, Amgen, Inc., Thousand Oaks, California |
| 202 |
Efficiency Improvements in the Discovery and Development of Novel
Antibody Format and Protein-Based Biotherapeutics Using
CaptureSelect® Affinity Ligands and Yeast Display Discovery Tools
Hendrik Adams and Pim Hermans
BAC bv (The BioAffinity Company), Huizerstraatweg 28, 1411 GP Naarden, Naarden,
The Netherlands |
| 203 |
Generation of Fully Human Antibodies Derived from Fab-on-phage Display
Libraries. Rapid Kinetic-based Screening of Fab Fragments for Lead
Identification
Marc Vanhove
Dyax s.a., Boulevard du Rectorat 27B, Building 22, B-4000 Liege (Sart-Tilman), Belgium |
| 204 |
Novel Approaches to Affinity Screening
Enrique Carredano, Katarina Öberg, Tryggve Bergander, Lena Kärf, Charlotte
Brink, Kristina Nilsson-Valimaa, Katarina Stenklo, Jan Bergström, Carina
Engstrand, Åsa Dahlstedt-Hagman, Niklas Pettersson, Mats Nilsson, Nils
Stafström, Karol Lacki, Bo-Lennart Johansson, Jean-Luc Maloisel,
GE Healthcare Biosciences AB, Uppsala, Sweden |
Roche Younger Investigators Award Program
Chair: A. Cecilia A. Roque, Universidade Nova de Lisboa, Caparica, Portugal
| |
Development of HIC Media Useful for Isolation of Proteins Carrying Single
Amino Acid Substitutions
Kristian Becker*, Elisabeth Hallgren**, Enrique Carredano**, Ronnie
Palmgren** and Leif Bülow**
*Department of Pure and Applied Biochemistry, Centre for Chemistry and Chemical
Engineering, Lund University Lund, Sweden **GE Healthcare Bio-Sciences AB, Uppsala,
Sweden |
| |
Development of New OMNiMIPs (One Monomer Molecularly Imprinted
Polymers)
Jason LeJeune and David Spivak
Department of Chemistry, Lousiana State University, Baton Rouge, LA, USA |
| |
Novel Affinity Ligands for the Purification of Antibody Fragments
Jonathan M. Haigh, Christopher R. Lowe
Institute of Biotechnology, University of Cambridge, Cambridge, UK |
| |
Conformational Flexibility and Kinetic Complexity in Antigen-antibody
Interactions
Katerina Kourentzi, Mohan Srinivasan, Sandra J. Smith-Gill and Richard C
Willson
Department of Chemical and Biomolecular Engineering, University of Houston, Houston,
TX, USA |
| |
Molecular Imprinted Polymers for Selective Protein Adsorption by Miniemulsion Polymerization
Marc Herold, Klaus Niedergall, Melanie Dettling, Yunxiao Wang, Guenter Tovar Fraunhofer-Institute for Interfacial Engineering and Biotechnology & Institute for Interfacial Engineering, University of Stuttgart, Stuttgart, Germany
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Tuesday July 10, 2007
Session 3: New Developments in Chromatography
Juan A. Asenjo, University of Chile, Santiago, Chile
| Chairman Introduction |
| 301 |
Mathematical Modeling of Elution Curves for a Protein Mixture in
Chromatography Applied to the Optimal Selection of Operating
Conditions
J.A. Asenjo and B.A. Andrews
Centre for Biochemical Engineering and Biotechnology, Department of Chemical
Engineering and Biotechnology, University of Chile, Beauchef 861, Santiago, Chile |
| 302 |
Affinity Interaction under Chaotropic Conditions
Rainer Hahn1,2, Waltraud Kaar2, Barbara Kanatschnig1, Sabine Geinstetter1,
Karin Ahrer1,2 and Alois Jungbauer1,2
1Austrian Center of Biopharmaceutical Technology, Muthgasse 18, 1190 Vienna, Austria
2Department of Biotechnology, University of Natural Resources and Applied Life
Sciences, Vienna, Muthgasse 18, 1190 Vienna, Austria |
| 303 |
Immunoaffinity Capillary Electrophoresis for the Identification and
Characterization of Toxic Biomarkers
Norberto A. Guzman
Johnson and Johnson Pharmaceutical Research and Development – Global Preclinical
Division, Raritan, New Jersey |
| 304 |
Biacore Applications for Effective Bio-therapeutic Development
Brian Lang1 and Fredrik Sundberg2
1Biacore, Inc. part of GE Healthcare, 800 Centennial Ave., Piscataway, NJ 08854
2GE Healthcare Life Sciences, Rapsgatan 7, 75450 Uppsala, Sweden |
Lunch Work-
shop |
Success Story of MabSelect
Victor Bornsztejn
GE Healthcare Bioprocess, 800 Centennial Ave., Piscataway, NJ 08854 USA |
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Session 4: Nano/Bio/Materials
Richard Willson, University of Houston, Houston Texas
| Chairman Introduction |
Pierce
Award
Lecture |
Molecular Recognition of Proteins on Surfaces and the Development of
Critical Hydrophobicity HIC
Herbert P. Jennissen
Institut für physiologsiche Chemie, Universität-Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany |
| 401 |
Analyte-Responsive Retro-reflectors for Biochemical Assays and
Diagnostics
Steven M. Kemper1, Tim Sherlock2, Kaajal D. Shah1, Paul Ruchhoeft2, Robert
L. Atmar3, and Richard C. Willson1
1Department of Chemical and Biomolecular Engineering,
2Department of Electrical and
Computer Engineering, University of Houston, Houston, TX 77204, 3Department of Molecular Virology and Microbiology, Baylor College of Medicine,
Houston, TX 77030 |
| 402 |
Gold Nanorod Substrates for Localized Surface Plasmon Resonance
Sensing
Jason H. Hafner, Kathryn M. Mayer, Seunghyun Lee, Hongwei Liao, Betty C.
Rostro, Peter T. Scully
Department of Physics & Astronomy, Department of Chemistry, Rice University,
Houston, TX, USA 77005 |
| 403 |
Discovery and Development of OMNiMIPs: One MoNomer Molecularly
Imprinted Polymers
David Spivak
Department of Chemistry, Louisiana State University, Baton Rouge, LA |
Panel
Dis-
cussion |
Trends in Label-free Interaction Analysis - Ashique Rafique (Regeneron), Mathew Kirtley (ForteBio), Brian Lang (GE Healthcare), Voula Kodoyianni (GWC Technologies) |
Wednesday July 11, 2007
Session 5: Insights into Intra- and Inter- Molecular Recognition
M.A. Vijayalakshmi, CBST, VIT University, TamilNadu, India
| Chairman Introduction |
| 501 |
Self-Assembly of Soft Molecular Networks: Crystal Design and Curvature
Michael Ward
Molecular Design Institute, Dept. of Chemistry, New York University, New York, NY |
| 502 |
Molecular Recognition of Foreign Sequences in Engineered 5S
Ribosomal RNA
Xing Zhang1, Ajish S. R. Potty2, George W. Jackson2, George E. Fox1, and
Richard C. Willson1, 2
Department of Biology and Biochemistry1 and Department of Chemical Engineering2,
University of Houston, Houston, TX |
| 503 |
Small-molecule-mediated Rescue of Protein Function by an Inducible
Proteolytic Shunt
Matthew Pratt and Tom Muir
Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York
Avenue, New York, NY 10021 |
Session 6: Protein Interactions In and On Cells
Irwin Chaiken, Drexel University, Philadelphia, PA
| Chairman Introduction |
| 601 |
Dynamic Visualization of Signaling Activities in Living Cells
Jin Zhang
Depts. Pharmacology/Molecular Sciences and Neuroscience, Johns Hopkins University
School of Medicine, Baltimore, MD |
| 602 |
Structure and Function of Eukaryotic RNA Exosomes
C.D. Lima, Q. Liu, J.C. Greimann
Program in Structural Biology, Sloan-Kettering Institute, New York, NY 10021 USA |
| 603 |
Electrophoretic Fingerprinting of HIV-1 Cell Interaction: a Novel Tool for
Development of Charge-Based Strategies
Fairhurst, D.1, Rowell, R.2, Monahan, I.3, Stieh, D.3, McNeil-Watson, F.4,
Morfesis, A.4, Romano, J.1, Shattock, RJ.3 and M. Mitchnick5
1International Partnership for Microbicides, Silver Spring, USA,
2University of Massachusetts, Amherst, USA,
3St. Georges Hospital Medical School, London, UK,
4Malvern Instruments Ltd., Malvern, UK,
5Particle Sciences Inc., Bethlehem, USA |
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Over-view
Irwin Chaiken, Drexel University, Philadelphia, PA |
Thursday July 12, 2007
Session 7: Viruses and Vaccines
Daniel Malamud, New York University Dental Center, New York, NY
| Chairman Introduction |
| 701 |
Ligand Recognition and Plasticity in HIV Envelope Glycoprotein gp120
Wayne A. Hendrickson1,2, Hui Xie2,3, Anil Korkut2, Danny Ng4 and Amos B.
Smith, III4
1Howard Hughes Medical Institute, 2Department of Biochemistry and Molecular
Biophysics, and 3Department of Pharmacology, Columbia University, New York, NY
10032 USA
4Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104 USA |
| 702 |
The Role of Antibodies in Preventing and Treating HIV Infection
Susan Zolla-Pazner
New York VA and NYU Medical Centers, New York, NY USA |
| 703 |
Biomolecule Recognition in Piezoelectric Immunosensors: Application of
Piezoimmunosensors for Detection of HIV1 Virion Infectivity Factor
Guilherme N.M. Ferreira1*, João M. Encarnação1, Luis Rosa1, Rogério
Rodrigues1, Luisa Pedro1, Frederico Aires da Silva2, João Gonçalves2
1IBB-Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e
Estrutural, Universidade do Algarve, 8000 Faro, Portugal.
2URIA-Centro de Patógenese Molecular, Faculdade de Farmácia, Universidade de
Lisboa, Lisbon, Portugal |
| 704 |
Interaction of gp340, a Glycoprotein in the Innate Immune System, with
HIV-1 env
Daniel Malamud
New York University Dental Center, New York, NY USA |
| |
ISMR Presidential Announcements |
Session 8: Drug Discovery and Diagnostics
Waseem Malick, Hoffmann - La Roche, Nutley, NJ
| Chairman Introduction |
| 801 |
The Economics of Personalized Medicine: Optimizing Incentives for
Innovation
M. J. Finley Austin
Hoffmann - La Roche, Nutley, NJ USA |
| 802 |
Biomimetic and Supramolecular Scaffolds for Multivalent Display
Kent Kirshenbaum
Department of Chemistry, New York University New York, NY 10003 USA |
| 803 |
Designing for Success: The Generation of Useful Leads with Small
Molecule Libraries
Robert A. Goodnow Jr.
Discovery Chemistry, Hoffmann-La Roche, Inc., Nutley, NJ USA |
| 804 |
Cancer Chemotherapy with an FDA Approved Transition State Analog
Enzyme Binder
Ronald Breslow
Department of Chemistry, Columbia University, New York, NY 10027 USA |
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Closing remarks
Announcement of Affinity 2009 (Iceland),
Hordur Filippusson |
View list of posters (to be inserted)
To read the abstract, open and/or download the Program
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