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Sunday August 14, 2005
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Welcome Reception |
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Welcome and Introduction
Chairman: Lars Hagel, GE Healthcare Uppsala, Sweden |
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Keynote Lecture
From system biology to molecular dynamics
William A. Goddard lll, California Institute of Technology, Pasadena, USA |
Monday August 15, 2005
Session 1: Modelling of surface interactions
Session chair: Karin Caldwell, Uppsala University, Uppsala, Sweden
| 101 |
Plenary Lecture
Bacterial adhesion under flow: bonds that strengthen under force.
Viola Vogel, Biologisch-Orientierte Materialwissenschaften, ETH, Zurich, Switzerland. |
| 102 |
A-priori prediction of protein affinity in chromatographic systems
using state-of-the-art structure-property multi-scale modeling techniques,
Asif Ladiwala1, Qiong Luo2, Ting Yang1, Curt M Breneman2 and Steven M. Cramer1.
1 Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street,
Troy, NY 12180, USA,
2 Department of Chemistry, Rensselaer Polytechnic Institute. |
| 103 |
Size Distribution of Hydrophobic Patches Allows for the Selection of
Hydrophobic Interaction Chromatography (HIC) Media for Protein
Purification.
Markus Laub, Kristin Zurlinden, Herbert P. Jennissen,
Institut für Physiologische Chemie, Universität Duisburg-Essen,
Hufelandstr. 55, D-45122 Essen, Germany |
| 104 |
On the Thermodynamics of Protein Chromatography
Jørgen M. Mollerup,
Department of Chemical Engineering, DTU, Building 229, DK-2800 Lyngby, Denmark |
Session 2: Characterisation of surface interactions
Session chair: Bo Mattiasson, University of Lund, Lund, Sweden
| 201 |
Plenary Lecture
Design and characterization of novel sensing devices:
From self-assembled monolayers to micro- and nanostructured hydrogels.
Bo Liedberg, Division of Molecular Physics, IFM, Linköping University, SE-581 83
Linköping, Sweden |
| 202 |
Weak affinity cromatography using carbohydrate binding modules
Reine Johansson¹, Lavinia Cicortas Gunnarsson², Mats Ohlin², Sten Ohlson¹
¹ Department of Chemistry and Biomedical Sciences, University of Kalmar, Kalmar, Sweden,² Department of Immunotechnology, Lund University, Lund, Sweden |
| 203 |
Structure-Based Antagonism of the HIV-1 Envelope Host Cell Receptor
Machine Through Conformational Entrapment by Dual Receptor Antagonists
Irwin Chaiken, Hosahudya Gopi, Karyn McFadden, Simon Cocklin and Sabine Baxter
Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia PA 19102 USA |
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Pierce Award Lecture
Large-scale affinity purification of protein complexes: getting functional
and structural insights into cellular assemblies
Bertrand Seraphin,
Centre de Génétique Moléculaire, CNRS, Gif sur Yvette Cedex, France |
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Discussion Forum: Weak and strong affinity interactions – pros and cons?
Chair: M.A. Vijayalakshmi, Université de Technologie de Compiègne, COMPIEGNE,
France |
Tuesday August 16, 2005
Session 3: Design of affinity ligands
Session chair: Jan-Christer Janson, Uppsala University, Uppsala, Sweden.
| 301 |
Plenary Lecture
Why is it so Difficult to Design Ligands that Bind to Proteins?
George M. Whiteside,
Department of Chemistry and Chemical Biology, Harvard University Cambridge MA 02138, USA |
| 302 |
Universal Method for Synthesis of Highly Selective Artificial Gel
Antibodies against Proteins, Viruses and Cells; Some Techniques to Study
the Selectivity; and Applications.
S. Hjertén1. N. Ghasemzadeh1, M.-C. Hjertén1, Á. Végvári1, I. Bacskay2, A. Kilár2, M. Rezeli2,
A. Takátsy2, F. Kilár2, A. Ballagi3, A. Elfwing3, H. Cheng4, J. Sedzik4, T. Aastrup5,
H. Andersson5
1Dept. of Biochemistry, Uppsala University, Uppsala, Sweden;
2Inst. of Bioanalysis, University of Pécs, Pécs, Hungary;
3Center for Surface Biochemistry, Uppsala Univeristy, Uppsala, Sweden;
4Dept. of Biosciences at Novum, Karolinska
Institutet, Stockholm, Sweden;
5Attana AB, Stockholm, Sweden |
| 303 |
Nano Imprint Biotechnology
Klaus Mosbach *, Lei Ye and Huiqi Zhang,
Center for Molecular Imprinting Lund University, Sweden |
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Young Investigator Award Presentations |
Session 4: Combinatorial strategies for ligand discovery
Session chair: Mathias Uhlén, Royal Institute of Technology, Stockholm, Sweden
| 401 |
Plenary Lecture
Mimicking natural combinatorial strategies for the creation and
selection of molecular diversity
Greg Winter,
MRC Laboratory of Molecular Biology, Hills Road, Cambridge |
| 402 |
Design of small organic molecule affi nity ligands
E. Carredano, A. Axén, H. Baumann, Oguz Ersoy,
GE Healthcare , Uppsala, Sweden |
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| 403 |
An Artificial Protein L (PpL) for the Purification of Immunoglobulins and
Fab Fragments by Affinity Chromatography
Jonathan M. Haigh1, Xiaoping Yang1, Erik Gimble2, Christopher R. Lowe1, 1Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK,
2Bioniqs Ltd. Heslington Hall, University of York, Heslington, York, UK. YO10 5DD, UK |
| 404 |
Reducing protein concentration range of biological samples using
combinatorial ligand libraries
E. Boschetti, L. Lomas,
Ciphergen Biosystems Inc. Fremont CA, USA |
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Discussion Forum:
Design of affinity ligands – are there any new approaches?
Chair: Mathias Uhlén, Royal Institute of Technology, Stockholm, Sweden |
Wednesday August 17, 2005
Session 5: Strategies for industrial affinity purifi cations
Session chair: Lars Hagel, GE Healthcare, Uppsala, Sweden
| 501 |
Plenary Lecture
Industrial Protein Purification Process Design: Integrating the Steps
from Raw Source to Final Product
Conan J. Fee,
Department of Materials & Process Engineering, University of Waikato, Private Bag 3105, Hamilton, New Zealand. |
| 502 |
Novel high capacity and high alkaline stable protein A affinity
chromatography media: characterization and engineering considerations
Rainer Hahn, Philipp Bauerhansl and Alois Jungbauer,
Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria |
| 503 |
Affinity adsorption processes for food industries: need or dream?
Karin Merck,
Agrotechnology and Food Innovations B.V., Bornsesteeg 59, 6708 PD, Wageningen, The Netherlands |
| 504 |
Selective and specific capturing of target molecules
E. Houtzager, G. de Roo, I. Vijn, K.J. Francoijs, P. Sijmons,
CatchMabs BV, Wageningen, the Netherlands |
Session 6: Molecular interactions for medical applications.
Session chair: Sten Ohlson, University of Kalmar, Kalmar, Sweden
| 601 |
Plenary Lecture
Applications of Smart Polymers as protein Conjugates
Allan S. Hoff man and Patrick Stayton (and many coworkers),
Department of Bioengineering, University of Washington, Seattle, WA 98195 USA |
| 602 |
Human Proteome Resource – strategies for protein discovery.
Sophia Hober,
Department of Biotechnlogy, AlbaNova University Center, Royal Institute of Technology (KTH), Stockholm, Sweden |
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Young Investigator Award Presentations |
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Gala Dinner at Uppsala Castle |
Thursday August 18, 2005
Session 6: Molecular interactions for medical applications, continued
Session chair: Sten Ohlson, University of Kalmar, Kalmar, Sweden
| 603 |
Plenary Lecture
PET, a tracer technology with many applications
B. Långström, G. Antoni, T. Kihlberg, F. Karimi, O. Rahman ,S. Estrada, O. Lindhe, H. Engler,
G. Blomqvist, O. Itsenko*, J. Barletta*, I. Velikyan*,J. Eriksson,
Uppsala Imanet AB, S-751 09 Uppsala, Sweden, *Dep. Org. Chem., University of Uppsala |
| 604 |
Affinity Purification and Characterization of an Anti-PEG IgM
George K Ehrlich,
Hoff mann-La Roche, 340 Kingsland Street , Nutley, NJ 07110 |
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Jerker Porath Award Lecture |
Session 7: Molecular interactions in the nano-format
Session Chair: Richard Willson, University of Huston, Huston, TX, USA
| 701 |
Plenary Lecture
Molecular assembly platform to direct bio-specifi c responses in
biomaterials, biosensors and targeted drug delivery
Marcus Textor,
BioInterfaceGroup, Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich,
CH-8093 Zurich, Switzerland |
| 702 |
Reversible and Directional Self-Assembly of Bio-Molecular Templates
for Nanotechnology Interconnects
Lian Wang*, Chelsea Benally*, Roberto Guzman*, Ye Yang‡, Pierre Deymier‡,
Heather McLaughlin+ Ian Jongeward+ and James Hoying**.
*Department of Chemical & Environmental Engineering. ‡Department of Material Science and Engineering.
+Department of Pediatrics. **Biomedical Engineering, University of Arizona, Tucson, AZ 85721 USA. |
| 703 |
Multi-Ligand Decorated Nanoparticles as Diagnostic
Platforms
K. Fromell, A. Sahlholm, M. Andersson and K.D. Caldwell,
Department of Surface Biotechnology Uppsala University, 75123 Uppsala, Sweden |
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Concluding remarks
Meeting chairman
Announcement of Affinity 2007 |
View list ofposters
To read the abstract, open and/or download the Program/Abstract book.
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